视黄酸诱导孤儿G蛋白偶联受体

视黄酸诱导孤儿G蛋白偶联受体（英语：Retinoic Acid-Inducible orphan G-protein-coupled receptor），缩写为RAIG，是一组四个密切相关的G蛋白偶联受体，其表达由视黄酸诱导。^[1]^[2]^[3]^[4]

这些蛋白质的确切功能尚未确定，但它们可能提供了视黄酸影响G蛋白信号转导级联的机制。此外，RAIG受体与卷曲类G蛋白偶联受体的成员相互作用，并似乎激活Wnt信号通路。^[5]

参考资料

^ Cheng Y, Lotan R. Molecular cloning and characterization of a novel retinoic acid-inducible gene that encodes a putative G protein-coupled receptor. J. Biol. Chem. 1998, 273 (52): 35008–15. PMID 9857033. doi:10.1074/jbc.273.52.35008 .
^ Bräuner-Osborne H, Krogsgaard-Larsen P. Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain. Genomics. 2000, 65 (2): 121–8. PMID 10783259. doi:10.1006/geno.2000.6164.
^ Robbins MJ, Michalovich D, Hill J, Calver AR, Medhurst AD, Gloger I, Sims M, Middlemiss DN, Pangalos MN. Molecular cloning and characterization of two novel retinoic acid-inducible orphan G-protein-coupled receptors (GPRC5B and GPRC5C). Genomics. 2000, 67 (1): 8–18. PMID 10945465. doi:10.1006/geno.2000.6226.
^ Bräuner-Osborne H, Jensen AA, Sheppard PO, Brodin B, Krogsgaard-Larsen P, O'Hara P. Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D. Biochim. Biophys. Acta. 2001, 1518 (3): 237–48. PMID 11311935. doi:10.1016/s0167-4781(01)00197-x.
^ Harada Y, Yokota C, Habas R, Slusarski DC, He X. Retinoic Acid-Inducible G Protein-Coupled Receptors Bind to Frizzled Receptors and May Activate Non-canonical Wnt Signaling. Biochem. Biophys. Res. Commun. 2007, 358 (4): 968–75. PMC 2854581 . PMID 17521608. doi:10.1016/j.bbrc.2007.04.208.