蛛毒素受体2

蛛毒素受体2
识别号
别名	ADGRL2；, CIRL2, CL2, LEC1, LPHH1, LPHN2, adhesion G protein-coupled receptor L2
外部ID	OMIM：607018 MGI：2139714 HomoloGene：22712 GeneCards：ADGRL2
基因位置（人类）
染色体	1号染色体
终止	81,993,932 bp
基因位置（小鼠）
染色体	小鼠3号染色体
终止	148,990,555 bp
RNA表达模式
	查阅更多表达数据
基因本体
分子功能	• G protein-coupled receptor activity; • transmembrane signaling receptor activity; • latrotoxin receptor activity; • signal transducer activity; • carbohydrate binding;
细胞组分	• integral component of membrane; • 膜; • 胞内; • integral component of plasma membrane; • neuron projection;
生物学过程	• G protein-coupled receptor signaling pathway; • cell surface receptor signaling pathway; • 信号转导; • adenylate cyclase-activating G protein-coupled receptor signaling pathway; • brain development;
	Sources:Amigo / QuickGO
直系同源
	23266
	99633
	ENSG00000117114
	ENSMUSG00000028184
	O95490
	Q8JZZ7
NM_001297704; NM_001297705; NM_001297706; NM_012302; NM_001330645;
	NM_001350698; NM_001350699; NM_001366002; NM_001366003; NM_001366004; NM_001366005; NM_001366006; NM_001366007; NM_001366008; NM_001366009; NM_001393349; NM_001393350; NM_001393351; NM_001393352; NM_001393353; NM_001393354
	NM_001081298
NP_001284633; NP_001284634; NP_001284635; NP_001317574; NP_036434;
	NP_001337627; NP_001337628; NP_001352931; NP_001352932; NP_001352933; NP_001352934; NP_001352935; NP_001352936; NP_001352937; NP_001352938
NP_001074767; NP_001392915; NP_001392916; NP_001392917; NP_001392918;
	NP_001392919; NP_001392920; NP_001392921; NP_001392922; NP_001392923; NP_001392924; NP_001392925; NP_001392926; NP_001392927; NP_001392928; NP_001392929; NP_001392930; NP_001392931; NP_001392932; NP_001392933; NP_001392934; NP_001392935; NP_001392936; NP_001392937; NP_001392938; NP_001392939; NP_001392940; NP_001392947; NP_001392948
	维基数据
查看/编辑人类	查看/编辑小鼠

蛛毒素受体2（英语：Latrophilin 2）是一种在人类中由ADGRL2基因编码的蛋白质。^[5]^[6]

该基因编码G蛋白偶联受体（GPCR）的蛛毒素受体亚家族成员。蛛毒素受体可能在细胞黏附和信号转导中发挥作用。在非人类物种的实验中，富含半胱氨酸的GPS（G蛋白偶联受体蛋白水解位点）结构域内的内源性蛋白水解切割产生两个亚基（一个大的细胞外N末端细胞黏附亚基和一个与GPCR的促胰液素/降钙素家族具有实质相似性的亚基）非共价结合在细胞膜上。虽然已经描述了几种转录变体，但仅确定了其中一种的生物学有效性。^[6]

参见

黏附G蛋白偶联受体

参考资料

^ ^1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000117114 - Ensembl, May 2017
^ ^2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000028184 - Ensembl, May 2017
^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
^ White GR, Varley JM, Heighway J. Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. Apr 2000, 1491 (1–3): 75–92. PMID 10760572. doi:10.1016/s0167-4781(00)00020-8.
^ ^6.0 ^6.1 Entrez Gene: LPHN2 latrophilin 2.

延申阅读

Südhof TC. alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins. Annual Review of Neuroscience. 2001, 24 (1): 933–62. PMID 11520923. doi:10.1146/annurev.neuro.24.1.933.
Ushkaryov YA, Volynski KE, Ashton AC. The multiple actions of black widow spider toxins and their selective use in neurosecretion studies. Toxicon. Apr 2004, 43 (5): 527–42. PMID 15066411. doi:10.1016/j.toxicon.2004.02.008.
Bonaldo MF, Lennon G, Soares MB. Normalization and subtraction: two approaches to facilitate gene discovery. Genome Research. Sep 1996, 6 (9): 791–806. PMID 8889548. doi:10.1101/gr.6.9.791 .
Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Research. Oct 1998, 5 (5): 277–86. PMID 9872452. doi:10.1093/dnares/5.5.277 .
White GR, Varley JM, Heighway J. Isolation and characterization of a human homologue of the latrophilin gene from a region of 1p31.1 implicated in breast cancer. Oncogene. Dec 1998, 17 (26): 3513–9. PMID 10030676. doi:10.1038/sj.onc.1202487 .
Kreienkamp HJ, Zitzer H, Gundelfinger ED, Richter D, Bockers TM. The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. The Journal of Biological Chemistry. Oct 2000, 275 (42): 32387–90. PMID 10964907. doi:10.1074/jbc.C000490200 .
Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB. The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. Genomics. Jul 2004, 84 (1): 23–33. PMID 15203201. doi:10.1016/j.ygeno.2003.12.004.
Clark TA, Schweitzer AC, Chen TX, Staples MK, Lu G, Wang H, Williams A, Blume JE. Discovery of tissue-specific exons using comprehensive human exon microarrays. Genome Biology. 2007, 8 (4): R64. PMC 1896007 . PMID 17456239. doi:10.1186/gb-2007-8-4-r64.

[refGRCh38Ensembl-1] 1.0 ^1.1 ^1.2 GRCh38: Ensembl release 89: ENSG00000117114 - Ensembl, May 2017

[refGRCm38Ensembl-2] 2.0 ^2.1 ^2.2 GRCm38: Ensembl release 89: ENSMUSG00000028184 - Ensembl, May 2017

[3] Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10760572-5] White GR, Varley JM, Heighway J. Genomic structure and expression profile of LPHH1, a 7TM gene variably expressed in breast cancer cell lines. Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. Apr 2000, 1491 (1–3): 75–92. PMID 10760572. doi:10.1016/s0167-4781(00)00020-8.

[entrez-6] 6.0 ^6.1 Entrez Gene: LPHN2 latrophilin 2.

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