氟替卡松

氟替卡松
临床资料
AHFS/Drugs.com	Monograph
怀孕分级	C(鼻腔内吸入);
给药途径	鼻腔内吸入，局部涂搽
ATC码	D07AC17 (WHO) R01AD08 R03BA05;
法律规范状态
法律规范	英：处方药（℞-only） (POM); 美：处方药（℞-only）;
药物动力学数据
生物利用度	0.51% (鼻腔内)
血浆蛋白结合率	91%
药物代谢	鼻腔内; 肝脏(CYP3A4-中介)
生物半衰期	10小时
排泄途径	肾脏
识别信息
	IUPAC命名法 S-(fluoromethyl) (6S,8S,9R,10S,11S,13S,14S,16R,17R)-; 6,9-difluoro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-; 6,7,8,11,12,14,15,16-octahydrocyclopenta[a]; phenanthrene-17-carbothioate; ;
CAS号	80474-14-2（（丙酸酯）） ; 90566-53-3
PubChem CID	5311101;
DrugBank	DB00588 ;
ChemSpider	4470631 ;
UNII	CUT2W21N7U;
KEGG	D07981 ;
ChEBI	CHEBI:5134 ;
ChEMBL	ChEMBL1201396 ;
CompTox Dashboard（英语：CompTox Chemicals Dashboard） (EPA)	DTXSID0044022 ;
化学信息
化学式	C22H27F3O4S
摩尔质量	444.508 g/mol
3D模型（JSmol（英语：JSmol））	交互式图像;
	SMILES O=C(SCF)[C@]3(O)[C@]2(C[C@H](O)[C@]4(F)[C@@]/1(\C(=C/C(=O)\C=C\1)[C@@H](F)C[C@H]4[C@@H]2C[C@H]3C)C)C;
	InChI InChI=1S/C22H27F3O4S/c1-11-6-13-14-8-16(24)15-7-12(26)4-5-19(15,2)21(14,25)17(27)9-20(13,3)22(11,29)18(28)30-10-23/h4-5,7,11,13-14,16-17,27,29H,6,8-10H2,1-3H3/t11-,13+,14+,16+,17+,19+,20+,21+,22+/m1/s1 ; Key:MGNNYOODZCAHBA-GQKYHHCASA-N ;

氟替卡松（英语：fluticasone）为一种综合的糖皮质激素。^[1]

与糠酸酯（furoate）或丙酸酯（propanoate)的合成品可以用为局部抗炎性、比如鼻炎方面：^[2]

参见

^ Briggs, Gerald G.; Freeman, Roger K.; Yaffe, Sumner J., Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk, Lippincott Williams & Wilkins: 600, 2012 [2013-10-28], ISBN 1451153597, （原始内容存档于2014-01-01）.
^ Spratto, George R.; Woods, Adrienne L., Delmar Nurse's Drug Handbook 2012, Cengage Learning: 748, 2012 [2013-10-28], ISBN 1111310653, （原始内容存档于2014-01-01）.

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