WS-12
| WS-12 | |
|---|---|
| |
| IUPAC名 (1R,2S,5R)-N-(4-Methoxyphenyl)-5-methyl-2-(propan-2-yl)cyclohexane-1-carboxamide | |
| 识别 | |
| CAS号 | 68489-09-8 |
| PubChem | 11266244 |
| ChemSpider | 9441255 |
| SMILES |
|
| 性质 | |
| 化学式 | C18H27NO2 |
| 摩尔质量 | 289.41 g·mol−1 |
| 若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。 | |
WS-12，化学式C18H27NO2，是一种含氮有机化合物，能作为离子通道TRPM8的强效选择性激动剂，与依色林相比，WS-12对TRPM8的激动剂效力略低，但其对TRPM8的选择性却高得多。[1][2][3][4][5]
参考文献
- ^ Bödding M, Wissenbach U, Flockerzi V. Characterisation of TRPM8 as a pharmacophore receptor. Cell Calcium. December 2007, 42 (6): 618–28. PMID 17517434. doi:10.1016/j.ceca.2007.03.005.
- ^ Sherkheli MA, Vogt-Eisele AK, Bura D, Beltrán Márques LR, Gisselmann G, Hatt H. Characterization of selective TRPM8 ligands and their structure activity response (S.A.R) relationship. Journal of Pharmacy & Pharmaceutical Sciences. 2010, 13 (2): 242–53. PMID 20816009. doi:10.18433/j3n88n
.
- ^ Liu B, Fan L, Balakrishna S, Sui A, Morris JB, Jordt SE. TRPM8 is the principal mediator of menthol-induced analgesia of acute and inflammatory pain. Pain. October 2013, 154 (10): 2169–77. PMC 3778045 . PMID 23820004. doi:10.1016/j.pain.2013.06.043.
- ^ Peixoto-Neves D, Soni H, Adebiyi A. Oxidant-induced increase in norepinephrine secretion from PC12 cells is dependent on TRPM8 channel-mediated intracellular calcium elevation. Biochemical and Biophysical Research Communications. November 2018, 506 (3): 709–715. PMID 30376995. S2CID 53107273. doi:10.1016/j.bbrc.2018.10.120.
- ^ Yin Y, Le SC, Hsu AL, Borgnia MJ, Yang H, Lee SY. Structural basis of cooling agent and lipid sensing by the cold-activated TRPM8 channel. Science. March 2019, 363 (6430). PMC 6478609 . PMID 30733385. doi:10.1126/science.aav9334 .
