Template:PBB/7157

肿瘤蛋白p53
PDB基于1TUP的渲染：P53与DNA结合
有效结构 PDB 直系同源检索：PDBe, RCSB PDB查询代码列表 1A1U、 1AIE、 1C26、 1DT7、 1GZH、 1H26、 1HS5、 1JSP、 1KZY、 1MA3、 1OLG、 1OLH、 1PES、 1PET、 1SAE、 1SAF、 1SAK、 1SAL、 1TSR、 1TUP、 1UOL、 1XQH、 1YC5、 1YCQ、 1YCR、 1YCS、 2AC0、 2ADY、 2AHI、 2ATA、 2B3G、 2BIM、 2BIN、 2BIO、 2BIP、 2BIQ、 2FEJ、 2FOJ、 2FOO、 2GS0、 2H1L、 2H2D、 2H2F、 2H4F、 2H4H、 2H4J、 2H59、 2J0Z、 2J10、 2J11、 2J1W、 2J1X、 2J1Y、 2J1Z、 2J20、 2J21、 2K8F、 2L14、 2LY4、 2OCJ、 2PCX、 2QVQ、 2QXA、 2QXB、 2QXC、 2VUK、 2WGX、 2X0U、 2X0V、 2X0W、 2XWR、 2YBG、 2Z5S、 2Z5T、 3D05、 3D06、 3D07、 3D08、 3D09、 3D0A、 3DAB、 3DAC、 3IGK、 3IGL、 3KMD、 3KZ8、 3LW1、 3PDH、 3Q01、 3Q05、 3Q06、 3SAK、 3TG5、 3TS8、 4AGL、 4AGM、 4AGN、 4AGO、 4AGP、 4AGQ
标识
代号	TP53; BCC7; LFS1; P53; TRP53
扩展标识	遗传学：191170 鼠基因：98834 同源基因：460 ChEMBL: 4096 GeneCards: TP53 Gene
基因本体论描述 分子功能 · RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription · RNA polymerase II transcription factor binding · RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription · protease binding · p53 binding · DNA binding · chromatin binding · damaged DNA binding · sequence-specific DNA binding transcription factor activity · copper ion binding · protein binding · ATP binding · transcription factor binding · zinc ion binding · enzyme binding · protein kinase binding · receptor tyrosine kinase binding · ubiquitin protein ligase binding · histone deacetylase regulator activity · histone acetyltransferase binding · identical protein binding · transcription regulatory region DNA binding · protein heterodimerization activity · protein N-terminus binding · chaperone binding · protein phosphatase 2A binding 细胞成分 · chromatin · nuclear chromatin · nucleus · nucleoplasm · replication fork · transcription factor TFIID complex · chromatin assembly complex · nucleolus · cytoplasm · mitochondrion · endoplasmic reticulum · cytosol · nuclear matrix · nuclear body · PML body · protein complex 生物过程 · protein import into nucleus、 translocation · cell cycle checkpoint · negative regulation of transcription from RNA polymerase II promoter · DNA strand renaturation · in utero embryonic development · somitogenesis · release of cytochrome c from mitochondria · T cell proliferation involved in immune response · B cell lineage commitment · T cell lineage commitment · base-excision repair · nucleotide-excision repair · double-strand break repair · regulation of transcription、 DNA-dependent · protein complex assembly · apoptotic process · induction of apoptosis · response to DNA damage stimulus · DNA damage response、 signal transduction by p53 class mediator resulting in cell cycle arrest · DNA damage response、 signal transduction by p53 class mediator resulting in transcription of p21 class mediator · ER overload response · cell cycle arrest · transforming growth factor beta receptor signaling pathway · Ras protein signal transduction · multicellular organismal development · gastrulation · negative regulation of neuroblast proliferation · central nervous system development · cell aging · blood coagulation · protein localization · negative regulation of DNA replication · cell proliferation · negative regulation of cell proliferation · determination of adult lifespan · rRNA transcription · response to salt stress · response to X-ray · response to gamma radiation · virus-host interaction · cell differentiation · negative regulation of cell growth · DNA damage response、 signal transduction by p53 class mediator · negative regulation of transforming growth factor beta receptor signaling pathway · positive regulation of histone deacetylation · mitotic cell cycle G1/S transition DNA damage checkpoint · positive regulation of protein oligomerization · T cell differentiation in thymus · cellular protein localization · cellular response to UV · multicellular organism growth · cellular response to drug · cellular response to glucose starvation · intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator · regulation of apoptotic process · positive regulation of apoptotic process · negative regulation of apoptotic process · positive regulation of neuron apoptotic process · negative regulation of transcription、 DNA-dependent · positive regulation of transcription、 DNA-dependent · positive regulation of transcription from RNA polymerase II promoter · response to antibiotic · regulation of mitochondrial membrane permeability · negative regulation of fibroblast proliferation · positive regulation of peptidyl-tyrosine phosphorylation · negative regulation of helicase activity · protein tetramerization · chromosome organization · neuron apoptotic process · positive regulation of thymocyte apoptotic process · positive regulation of cell cycle arrest · cellular response to hypoxia · cellular response to ionizing radiation · mitotic cell cycle arrest · intrinsic apoptotic signaling pathway by p53 class mediator · positive regulation of release of cytochrome c from mitochondria · positive regulation of cell aging · replicative senescence · oxidative stress-induced premature senescence · intrinsic apoptotic signaling pathway · positive regulation of reactive oxygen species metabolic process · positive regulation of intrinsic apoptotic signaling pathway Sources: Amigo / QuickGO
RNA表达模式
更多表达数据
直系同源体
物种	人类	小鼠
Entrez	7157	22059
Ensembl	ENSG00000141510	ENSMUSG00000059552
UniProt	P04637	P02340
mRNA序列	NM_000546.5	NM_001127233.1
蛋白序列	NP_000537.3	NP_001120705.1
基因位置	Chr 17: 7.57 – 7.59 Mb	Chr 11: 69.58 – 69.59 Mb
PubMed查询	[1]	[2]