CYP11C1
cytochrome P450, family 11, subfamily c, polypeptide 1 | |
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标识 | |
生物 | |
符号 | CYP11C1 |
Entrez | 791124 |
RefSeq (mRNA) | NM_001080204.1 |
RefSeq (蛋白质) | NP_001073673.1 |
UniProt | A1XRK1 |
其他数据 | |
EC number | 1.14.15.4 |
染色体 | 16: 54.46 - 54.48 Mb |
Cyp11c1是鱼类的一种编码CYP450单加氧酶的基因,最早发现于模式动物斑马鱼(学名:Danio rerio),负责催化皮质醇和11-酮睾酮(11-KT)的形成[1][2],11-KT是斑马鱼的内源性雄激素。
参考文献
- ^ Zhang Q, Ye D, Wang H, Wang Y, Hu W, Sun Y. Zebrafish cyp11c1 Knockout Reveals the Roles of 11-ketotestosterone and Cortisol in Sexual Development and Reproduction. Endocrinology. June 2020, 161 (6). PMID 32222764. doi:10.1210/endocr/bqaa048.
- ^ Zheng Q, Xiao H, Shi H, Wang T, Sun L, Tao W, et al. Loss of Cyp11c1 causes delayed spermatogenesis due to the absence of 11-ketotestosterone. The Journal of Endocrinology. March 2020, 244 (3): 487–499. PMID 31910154. doi:10.1530/JOE-19-0438.