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4-甲基溴苄

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4-甲基溴苄
英文名 4-Methylbenzyl bromide
别名 对甲基溴苄
4-甲基苄溴
4-甲基溴化苄
4-溴甲基甲苯
识别
CAS号 104-81-4  checkY
SMILES
 
  • Cc1ccc(CBr)cc1
性质
化学式 C8H9Br
摩尔质量 185.06 g·mol−1
密度 1.324 g·cm−3[1]
熔点 35.3 °C（308.4 K）[2]
沸点 220 °C（493 K）[3]
相关物质
其他阴离子 4-甲基氯化苄
其他阳离子 溴化苄
若非注明，所有数据均出自标准状态（25 ℃，100 kPa）下。

4-甲基溴苄是一种有机化合物，化学式为C8H9Br。它可由4-甲基苯甲醇和三甲基溴硅烷在室温反应得到，[4]溴化试剂也可以选用三溴化磷[5]或六溴丙酮[6]。它和叠氮化钠在二甲基亚砜中反应，可以得到4-甲基叠氮化苄[7]；和苯甲酸在碳酸铯存在下于乙腈中反应，得到苯甲酸-4-甲基苯甲酯。[8]

参考文献

  1. ^ "Hazardous Substances Data Bank" data were obtained from the National Library of Medicine (US). Retrieved from SciFinder. [2020-05-23].
  2. ^ C. W. L. Bevan. 270. Polar effects of alkyl groups in the absence of vicinal steric effects. Journal of the Chemical Society (Resumed). 1960: 1347 [2020-05-29]. ISSN 0368-1769. doi:10.1039/jr9600001347 （英语）. 
  3. ^ "PhysProp" data were obtained from Syracuse Research Corporation of Syracuse, New York (US). Retrieved from SciFinder. [2020-05-23].
  4. ^ Njomza Ajvazi, Stojan Stavber. Direct halogenation of alcohols with halosilanes under catalyst- and organic solvent-free reaction conditions. Tetrahedron Letters. 2016-06, 57 (22): 2430–2433 [2020-05-29]. doi:10.1016/j.tetlet.2016.04.083. （原始内容存档于2018-06-30） （英语）. 
  5. ^ Francis Giraud, Cedric Loge, Fabrice Pagniez, Damien Crepin, Sophie Barres, Carine Picot, Patrice Le Pape, Marc Le Borgne. Design, synthesis and evaluation of 3-(imidazol- 1-ylmethyl)indoles as antileishmanial agents. Part II. Journal of Enzyme Inhibition and Medicinal Chemistry. 2009-10, 24 (5): 1067–1075 [2020-05-29]. ISSN 1475-6366. doi:10.1080/14756360802610795 （英语）. 
  6. ^ Kara M. Joseph, Isabel Larraza-Sanchez. Synthesis of benzyl bromides with hexabromoacetone: an alternative path to drug intermediates. Tetrahedron Letters. 2011-01, 52 (1): 13–16 [2020-05-29]. doi:10.1016/j.tetlet.2010.10.133. （原始内容存档于2018-06-05） （英语）. 
  7. ^ Ming Li, Kun Dong, Yubin Zheng, Wangze Song. Copper-catalyzed cascade click/nucleophilic substitution reaction to access fully substituted triazolyl-organosulfurs. Organic & Biomolecular Chemistry. 2019, 17 (46): 9933–9941 [2020-05-29]. ISSN 1477-0520. doi:10.1039/C9OB02081K （英语）. 
  8. ^ Jincheng Mao, Xiaojiang Yang, Hong Yan, Yue He, Yongming Li, Jinzhou Zhao. Effective Synthesis of Benzyl 3-Phenylpropiolates Via Copper(I)-Catalyzed Esterification of Alkynoic Acids with Benzyl Halides Under Ligand-Free Conditions. Catalysis Letters. 2016-05, 146 (5): 886–892 [2020-05-29]. ISSN 1011-372X. doi:10.1007/s10562-015-1690-5 （英语）. 
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