蛋白三聚體
蛋白三聚體(protein trimer)為三個蛋白質聚合而成的複合體,一般是以非共價作用力聚合而成。由三個相同蛋白質形成的三聚體稱為同源三聚體,如第三型膠原蛋白[1]、真核生物的DNA夾(由三個增殖細胞核抗原組成)[2]和冠狀病毒表面的刺突[3];由三個相異蛋白質形成的三聚體則稱為異源三聚體,如古菌的DNA夾(由PCNA1、PCNA2和PCNA3組成)[2]。
參考文獻
- ^ Kuivaniemi, Helena; Tromp, Gerard. Type III collagen (COL3A1): Gene and protein structure, tissue distribution, and associated diseases. Gene. 2019, 707: 151–171. ISSN 0378-1119. doi:10.1016/j.gene.2019.05.003.
- ^ 2.0 2.1 Moldovan, George-Lucian; Pfander, Boris; Jentsch, Stefan. PCNA, the Maestro of the Replication Fork. Cell. 2007, 129 (4): 665–679. ISSN 0092-8674. doi:10.1016/j.cell.2007.05.003.
- ^ Walls, Alexandra C.; Tortorici, M. Alejandra; Bosch, Berend-Jan; Frenz, Brandon; Rottier, Peter J. M.; DiMaio, Frank; Rey, Félix A.; Veesler, David. Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Nature. 2016, 531 (7592): 114–117. ISSN 0028-0836. doi:10.1038/nature16988.