组氨醇脱氢酶（英語：histidinol dehydrogenase，EC 1.1.1.23 （页面存档备份，存于互联网档案馆））是一种以NAD+或NADP+为受体、作用于供体CH-OH基团上的氧化还原酶。这种酶能催化以下酶促反应：
- L-组氨醇 + 2 NAD+ + H2O
L-组氨酸 + 2 NADH + 3 H+
组氨醇脱氢酶也能氧化组氨醛。在细菌、真菌和植物细胞中，组氨醇脱氢酶主要负责催化组氨酸生物合成的最后一步化学反应——组氨醇的四电子氧化反应。细菌的组氨醇脱氢酶是一个单链多肽；真菌的组氨醇脱氢酶则是一个多功能酶的C端结构域，可以催化组氨酸合成过程中的3个反应；植物的组氨醇脱氢酶则是由细胞核基因编码的蛋白质前体，需被转运至叶绿体后才能发挥作用。[1][2][3]
参考文献
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- ^ Cowan-Jacob SW, Rahuel J, Nagai A, Iwasaki G, Ohta D. Crystallization and preliminary crystallographic analysis of cabbage histidinol dehydrogenase. Acta Crystallogr. D Biol. Crystallogr. November 1996, 52 (Pt 6): 1188–90. PMID 15299582. doi:10.1107/S0907444996008396.
- ^ Barbosa JA, Sivaraman J, Li Y, Larocque R, Matte A, Schrag JD, Cygler M. Mechanism of action and NAD+-binding mode revealed by the crystal structure of L-histidinol dehydrogenase. Proc. Natl. Acad. Sci. U.S.A. February 2002, 99 (4): 1859–64. PMC 122284 . PMID 11842181. doi:10.1073/pnas.022476199.
- Adams E. Enzymatic synthesis of histidine from histidinol. J. Biol. Chem. 1954, 209 (2): 829–846. PMID 13192138.
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- Yourno J, InoI. Purification and crystallization of histidinol dehydrogenase fromSalmonella typhimurium LT-2. J. Biol. Chem. 1968, 243 (12): 3273–6. PMID 4872177.
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