四硝酸二氯六氨二(1,6-己二胺)合三铂
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臨床資料 | |
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ATC碼 |
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识别信息 | |
CAS号 | 172903-00-3 ![]() |
UNII | |
ChEBI | |
化学信息 | |
化学式 | C12H50Cl2N14O12Pt3 |
摩尔质量 | 1,238.77 g·mol−1 |
3D模型(JSmol) | |
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四硝酸二氯六氨二(1,6-己二胺)合三铂是一种配位化合物,化学式为[ClPt(NH3)2]2μ-{trans-Pt(NH3)2[H2N(CH2)6NH2]2}(NO3)4,有专利报道了它的合成。[1]它具有抗癌活性,在对三种卵巢瘤和四种黑色素瘤的研究中发现它的IC50比顺铂至少低20倍。[2]
参考文献
- ^ Valsecchi, Mariella; Conti, Marco; Del Greco, Luisa; Bugatti, Carlo; Menta, Ernesto; Giuliani, Ferdinando C.; Manzotti, Carla; Spinelli, Silvano; Farrell, Nicholas. Trinuclear cationic platinum complexes having antitumor activity and pharmaceutical compositions containing them. 1995. WO9526968.
- ^ Carla Manzotti; Graziella Pratesi; Ernesto Menta; Roberto Di Domenico; Ennio Cavalletti; Heinz H. Fiebig; Lloyd R. Kelland; Nicholas Farrell; Donatella Polizzi; Rosanna Supino; Gabriella Pezzoni; Franco Zunino. BBR 3464: A Novel Triplatinum Complex, Exhibiting a Preclinical Profile of Antitumor Efficacy Different from Cisplatin. Clin Cancer Res (2000) 6 (7): 2626–2634.
延伸阅读
- Michael E. Oehlsen; Yun Qu; Nicholas Farrell. Reaction of Polynuclear Platinum Antitumor Compounds with Reduced Glutathione Studied by Multinuclear (1H, 1H−15N Gradient Heteronuclear Single-Quantum Coherence, and 195Pt) NMR Spectroscopy. Inorg. Chem. 2003, 42, 18, 5498–5506. doi:10.1021/ic030045b.