转化生长因子-α

转化生长因子-α
转化生长因子-α
	PDB rendering based on 1mox.
有效结构
PDB	直系同源检索：PDBe, RCSB
PDB查询代码列表
	1GK5, 1MOX, 1YUF, 1YUG, 2TGF, 3E50, 3TGF, 4TGF
标识
代号	TGFA; TFGA
扩展标识	遗传学：190170 鼠基因：98724 同源基因：2431 GeneCards: TGFA Gene
基因本体论描述
分子功能	· glycoprotein binding; · MAP kinase kinase activity; · epidermal growth factor receptor binding; · protein binding; · growth factor activity;
细胞成分	· extracellular space; · nucleus; · plasma membrane; · cell surface; · integral to membrane; · basolateral plasma membrane; · cytoplasmic vesicle; · perinuclear region of cytoplasm;
生物过程	· MAPK cascade; · activation of MAPK activity; · angiogenesis; · epidermal growth factor receptor signaling pathway; · cell proliferation; · wound healing; · response to drug; · negative regulation of apoptotic process; · positive regulation of epidermal growth factor-activated receptor activity; · positive regulation of mitosis; · positive regulation of epithelial cell proliferation; · positive regulation of cell division; · mammary gland alveolus development;
	Sources: Amigo / QuickGO
RNA表达模式
	更多表达数据
直系同源体
物种	人类
Entrez	7039
Ensembl	ENSG00000163235
UniProt	P01135
mRNA序列	NM_001099691
蛋白序列	NP_001093161
基因位置	Chr 2:; 70.67 – 70.78 Mb
PubMed查询	[1]
	查; 论; 编;

转化生长因子-α（英语：Transforming growth factor - α，简称TGF-α）是一小分子的多肽。可以诱导上皮发育，可以使多种细胞转化。与表皮生长因子的氨基酸顺序相似。在某些人类癌症中有上调。转化生长因子-α是由巨噬细胞,脑细胞和表皮细胞产生的。

与表皮生长因子类似，转化生长因子-α通过与细胞表面的受体表皮生长因子受体(EGFR)结合而起作用。^[1]^[2]与表皮生长因子受体的高亲和力结合，激发受体内在的酪氨酸激酶的活性，从而启动了信号传导级联而导致多种生物化学变化，细胞内钙水平上升, 增加糖酵解与蛋白质合成, 增加某些基因(包括表皮生长因子受体)的表达, 最终导致DNA合成和细胞增殖。

参看

参考文献

^ Downward J, Parker P, Waterfield MD. Autophosphorylation sites on the epidermal growth factor receptor. Nature. 1984 Oct 4-10;311(5985):483-5
^ Kramer, A.; Yang, F.-C.; Snodgrass, P.; Li, X.; Scammell, T. E.; Davis, F. C.; Weitz, C. J. : Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science 294: 2511-2515, 2001.

外部链接

[1] Downward J, Parker P, Waterfield MD. Autophosphorylation sites on the epidermal growth factor receptor. Nature. 1984 Oct 4-10;311(5985):483-5

[2] Kramer, A.; Yang, F.-C.; Snodgrass, P.; Li, X.; Scammell, T. E.; Davis, F. C.; Weitz, C. J. : Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science 294: 2511-2515, 2001.

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