Serous carcinoma is a less common form of endometrial cancer. It is extremely aggressive and tends to arise in the setting of atrophy. Classically, it affects post-menopausal women.

Features

• Columnar (or cuboidal) cells with marked nuclear size variation and irregularity of the nuclear membrane.
• Cilia.
• Psammoma bodies - present in approximately 40-50% of tumours.
• Papillae - nipple-shaped structures with fibrovascular cores, not always present; ergo, uterine papillary serous carinoma may be a misnomer.

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  Animation showing 3-D nature of cluster.
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  Component of animation.
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  Component of animation.
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  Another case.

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  Low mag.
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  High mag.