高車前素

高車前素
	IUPAC名; 4′,5,7-Trihydroxy-6-methoxyflavone
識別
CAS號	1447-88-7
PubChem	5281628
ChemSpider	4444947
SMILES	COc1c(O)cc2oc(cc(=O)c2c1O)-c1ccc(O)cc1;
InChI	1/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3;
InChIKey	IHFBPDAQLQOCBX-UHFFFAOYAV
EINECS	802-856-8
ChEBI	75902
KEGG	C10058
性質
化學式	C16H12O6
	若非註明，所有數據均出自標準狀態（25 ℃，100 kPa）下。

高車前素（英語：Hispidulin，也稱為5,7,4'-三羥基-6-甲氧基黃酮，5,7,4'-Trihydroxy-6-methoxyflavone）是一種野黃芩素衍生的6-O-甲基化黃酮，分子式C₁₆H₁₂O₆，存在於芙蓉菊屬、蒿屬、鼠尾草屬等多種植物中^[1]，可穿過血腦屏障^[2]，對實驗大鼠有抗痙攣作用^[3]。

參考文獻

^ Patel, K; Patel, DK. Medicinal importance, pharmacological activities, and analytical aspects of hispidulin: A concise report.. Journal of traditional and complementary medicine. 2017-07, 7 (3): 360–366. PMID 28725632. doi:10.1016/j.jtcme.2016.11.003.
^ Kavvadias, D; Sand, P; Youdim, KA; Qaiser, MZ; Rice-Evans, C; Baur, R; Sigel, E; Rausch, WD; Riederer, P; Schreier, P. The flavone hispidulin, a benzodiazepine receptor ligand with positive allosteric properties, traverses the blood-brain barrier and exhibits anticonvulsive effects.. British journal of pharmacology. 2004-07, 142 (5): 811–20. PMID 15231642. doi:10.1038/sj.bjp.0705828.
^ Lin, Tzu-Yu; Lu, Cheng-Wei; Wang, Chia-Chuan; Lu, Jyh-Feng; Wang, Su-Jane. Hispidulin inhibits the release of glutamate in rat cerebrocortical nerve terminals. Toxicology and Applied Pharmacology. 2012-09, 263 (2): 233–243. doi:10.1016/j.taap.2012.06.015.